An atmospheric pressure ionization source based on desorption electrospray ionization technology (DESI) for ion cyclotron resonance mass spectrometry

An atmospheric pressure ionization source based on desorption electrospray ionization technology for a bench-top hybrid FTICR mass spectrometer is described. The ion source was characterized using low-molecular-weight-weight pharmaceutical samples. The dependences of signal intensities on various experimental parameters (solvent composition, surface temperature, spray voltage, etc.) were studied. Based on the results obtained, plausible mechanisms of desorption electrospray ionization for the analytes under the study are discussed. Keywords: mass spectrometry, atmospheric pressure ionization sources, desorption electrospray ionization. DOI: 10.1134/S1061934811140024
INTRODUCTION Nowadays mass spectrometry occupies the leading position among the methods of rapid and continuous analysis of the ecological state of the environment; it is widely used in criminology and [...]