Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

Authors :: Koitabashi, Norimichi
Danner, Thomas
Zaiman, Ari L.
Pinto, Yigal M.
Rowell, Janelle
Mankowski, Joseph
Zhang, Dou
Nakamura, Taishi
Takimoto, Eiki
Kass, David A.
Source :: Journal of Clinical Investigation. June 1, 2011, Vol. 121 Issue 6, p2301, 12 p.
Publication Year :: 2011
Abstract: The cardiac pathological response to sustained pressure overload involves myocyte hypertrophy and dysfunction along with interstitial changes such as fibrosis and reduced capillary density. These changes are orchestrated by mechanical [...]

Subjects :: Transforming growth factors
Bone morphogenetic proteins
Health care industry

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