Electrophoretic determination of Phenyl and p-bromophenyl substituted 1H,2H,3H,4H-pyrido[4,3-d]pyrimidinium diiodobromides

Phenyl and p-bromophenyl substituted 1H,2H,3H,4H-pyrido[4,3-d]pyrimidinium diiodobromides have been identified and determined by capillary zone electrophoresis on an unmodified quartz capillary It has been found that an increase in the number of bromine atoms in the structure of 1H,2H,3H,4H-pyrido [4,3-d]pyrimidinium derivatives consecutively decreases the electrophoretic mobility of the cations. The developed method makes possible the determination pyrido [4,3-d]pyrimidiuum derivatives in the concentration range (0.03-0.25) mM with the [c.sub.mln](3.1-10.0) µM. Keywords: 1H,2H,3H,4H-pyrido [4,3-d]pyrimidinium derivatives, capillary zone electrophoresis DOI: 10.1134/S1061934813110063
INTRODUCTION Heterocyclic compounds based on pyridopyrimidine are widely spread because of their high biological activity and use in pharmaceutical chemistry [1]. The pyridine ring is part of the structure of [...]