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Lipotoxicity disrupts incretin-regulated human β cell connectivity

Authors :
Hodson, David J.
Mitchell, Ryan K.
Bellomo, Elisa A.
Sun, Gao
Vinet, Laurent
Meda, Paolo
Li, Daliang
Li, Wen-Hong
Bugliani, Marco
Marchetti, Piero
Bosco, Domenico
Piemonti, Lorenzo
Johnson, Paul
Hughes, Stephen J.
Rutter, Guy A.
Source :
Journal of Clinical Investigation. October 1, 2013, Vol. 123 Issue 10, p4182, 13 p.
Publication Year :
2013

Abstract

Pancreatic β cell dysfunction is pathognomonic of type 2 diabetes mellitus (T2DM) and is driven by environmental and genetic factors. β cell responses to glucose and to incretins such as [...]

Details

Language :
English
ISSN :
00219738
Volume :
123
Issue :
10
Database :
Gale General OneFile
Journal :
Journal of Clinical Investigation
Publication Type :
Academic Journal
Accession number :
edsgcl.345695882
Full Text :
https://doi.org/10.1172/JCI68459