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Zinc, insulin, and the liver: a menage a trois

Authors :
O'Halloran, Thomas V.
Kebede, Melkam
Philips, Steven J.
Attie, Alan D.
Source :
Journal of Clinical Investigation. October 1, 2013, Vol. 123 Issue 10, p4136, 4 p.
Publication Year :
2013

Abstract

Insulin and [Zn.sup.2+] enjoy a multivalent relationship. [Zn.sup.2+] binds insulin in pancreatic β cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in response to physiological [...]

Details

Language :
English
ISSN :
00219738
Volume :
123
Issue :
10
Database :
Gale General OneFile
Journal :
Journal of Clinical Investigation
Publication Type :
Academic Journal
Accession number :
edsgcl.345695876
Full Text :
https://doi.org/10.1172/JCI72325