Asthma in children in relation to pre-term birth and fetal growth restriction

To assess the impact of parental asthma on risk of pre-term birth (PTB) and intrauterine growth restriction, and their subsequent association with childhood asthma. Three sequential cross-sectional surveys were conducted in 1993 (3,746), 1998 (1,964) and 2006 (1,074) in the same 15 schools among 5-11 year old children in Merseyside using the same respiratory health questionnaire completed by parents (sample size in brackets). Between 1993 and 2006, prevalence of PTB varied between 12.4 and 15.2%, and of small for gestational age (SGA or growth restricted) babies between 2.1 and 4.6%, and maternal asthma prevalence between 8.1 and 13.4%. For the combined surveys mothers with asthma were more likely to have a PTB than non-asthmatic mothers (OR 1.39, 95% CI 1.10-1.95, p < 0.001), and in the 2006 survey were more likely to have an SGA baby. 40.9% of PTBs of asthmatic mothers developed doctor diagnosed asthma compared to 34.3% for term babies (adjusted OR 1.65, 1.34-2.04, p < 0.001). The corresponding estimates for the symptom triad of cough, wheeze and breathlessness were 19.4 and 17.6% (adjusted OR 1.78, 0.79-3.98). Conversely SGA babies were less likely to develop doctor diagnosed asthma (adjusted OR 0.49, 0.27-0.90, p < 0.021), or the symptom triad of cough, wheeze and breathlessness (adjusted OR 0.22, 0.05-0.97, p < 0.043), whether or not the mother was asthmatic. Maternal asthma is an independent risk factor for PTB which predisposes to childhood asthma. Intrauterine growth restriction was protective against childhood asthma. Keywords Asthma * Pre-term birth * Small for gestational age * Maternal asthma * Smoking * Children
Introduction Previous studies evaluating the relationship between parental asthma, birth outcomes and prevalence of asthma in children have shown inconsistent and weak associations [1-3] and have not evaluated the extent [...]