Computerized Decision Support for Medication Dosing in Renal Insufficiency: A Randomized, Controlled Trial

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2010.03.025 Byline: Kevin M. Terrell (a)(b)(c)(d), Anthony J. Perkins (b), Siu L. Hui (b)(c)(d), Christopher M. Callahan (b)(c)(d), Paul R. Dexter (c)(d), Douglas K. Miller (b)(c)(d) Abstract: Emergency physicians prescribe several discharge medications that require dosage adjustment for patients with renal disease. The hypothesis for this research was that decision support in a computerized physician order entry system would reduce the rate of excessive medication dosing for patients with renal impairment. Author Affiliation: (a) Department of Emergency Medicine, Indianapolis, IN (b) Indiana University Center for Aging Research, Indianapolis, IN (c) Regenstrief Institute, Inc., Indianapolis, IN (d) Indiana University School of Medicine, Indianapolis, IN Article History: Received 7 December 2009; Revised 9 February 2010; Revised 12 February 2010; Revised 7 March 2010; Accepted 11 March 2010 Article Note: (footnote) Provide feedback on this article at the journal's Web site, www.annemergmed.com., Author contributions: All authors participated in conception of the study and designing the trial. KMT, AJP, SLH, and CMC obtained research funding. KMT, AJP, CMC, PRD, and DKM supervised the conduct of the trial and data collection. AJP and SLH managed the data and analyzed the data. KMT drafted the manuscript, and all authors contributed substantially to its revision. KMT takes responsibility for the paper as a whole., Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. This research was supported by Dr. Terrell's Dennis W. Jahnigen Career Development Award, which is funded by the American Geriatrics Society, the John A. Hartford Foundation, and Atlantic Philanthropies Inc. , Supervising editor: Steven M. Green, MD, Publication dates: Available online May 8, 2010., Reprints not available from authors., Please see page 624 for the Editor's Capsule Summary of this article.