The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

Authors :: Sonati, Tiziana
Reimann, Regina R.
Falsig, Jeppe
Baral, Pravas Kumar
O'Connor, Tracy
Hornemann, Simone
Yaganoglu, Sine
Li, Bei
Herrmann, Uli S.
Wieland, Barbara
Swayampakula, Mridula
Rahman, Muhammad Hafizur
Das, Dipankar
Kav, Nat
Riek, Roland
Liberski, Pawel P.
James, Michael N.G.
Aguzzi, Adriano
Source :: Nature. September 5, 2013, Vol. 501 Issue 7465, p102, 8 p.
Publication Year :: 2013
Abstract: Prion infections cause lethal neurodegeneration. This process requires the cellular prion protein ([PrP.sup.C]; ref. 1), which contains a globular domain hinged to a long amino-proximal flexible tail (2). Here we [...]

Subjects :: Viral antibodies -- Dosage and administration
Prions -- Physiological aspects -- Health aspects
Drug interactions -- Research
Antibodies -- Dosage and administration
Environmental issues
Science and technology
Zoology and wildlife conservation

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