Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

Authors :: Laedermann, Cedric J.
Cachemaille, Matthieu
Kirschmann, Guylene
Pertin, Marie
Gosselin, Romain-Daniel
Chang, Isabelle
Albesa, Maxime
Towne, Chris
Schneider, Bernard L.
Kellenberger, Stephan
Abriel, Hugues
Decosterd, Isabelle
Source :: Journal of Clinical Investigation. July 1, 2013, Vol. 123 Issue 7, p3002, 12 p.
Publication Year :: 2013
Abstract: Peripheral neuropathic pain is a disabling condition resulting from nerve injury. It is characterized by the dysregulation of voltage-gated sodium channels ([Na.sub.v]s) expressed in dorsal root ganglion (DRG) sensory neurons. [...]

Subjects :: Ubiquitin -- Health aspects
Ligases -- Health aspects
Peripheral nerve diseases -- Research
Health care industry

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