HIF1α and HIF2α independently activate SRC to promote melanoma metastases

Authors :: Hanna, Sara C.
Krishnan, Bhavani
Bailey, Sean T.
Moschos, Stergios J.
Kuan, Pei-Fen
Shimamura, Takeshi
Osborne, Lukas D.
Siegel, Marni B.
Duncan, Lyn M.
O'Brien, III, E. Tim
Superfine, Richard
Miller, C. Ryan
Simon, M. Celeste
Wong, Kwok-Kin
Kim, William Y.
Source :: Journal of Clinical Investigation. May 1, 2013, Vol. 123 Issue 5, p2078, 16 p.
Publication Year :: 2013
Abstract: Malignant melanoma is characterized by a propensity for early lymphatic and hematogenous spread. The hypoxia-inducible factor (HIF) family of transcription factors is upregulated in melanoma by key oncogenic drivers. HIFs [...]