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ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss

Authors :
Chen, Yu
Chi, Ping
Rockowitz, Shira
Iaquinta, Phillip J.
Shamu, Tambudzai
Shukla, Shipra
Gao, Dong
Sirota, Inna
Carver, Brett S.
Wongvipat, John
Scher, Howard I.
Zheng, Deyou
Sawyers, Charles L.
Source :
Nature Medicine. August 1, 2013, Vol. 19 Issue 8, p1023, 9 p.
Publication Year :
2013

Abstract

Studies of ETS-mediated prostate oncogenesis have been hampered by a lack of suitable experimental systems. Here we describe a new conditional mouse model that shows robust, homogenous ERG expression throughout [...]

Details

Language :
English
ISSN :
10788956
Volume :
19
Issue :
8
Database :
Gale General OneFile
Journal :
Nature Medicine
Publication Type :
Academic Journal
Accession number :
edsgcl.340425545
Full Text :
https://doi.org/10.1038/nm.3216