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Hypothalamic glucagon signaling inhibits hepatic glucose production

Authors :
Mighiu, Patricia I.
Yu, Jessica T.Y.
Filippi, Beatrice M.
Abraham, Mona A.
Chari, Madhu
Lam, Carol K.L.
Yang, Clair S.
Christian, Nikita R.
Charron, Maureen J.
Lam, Tony K.T.
Source :
Nature Medicine. June 1, 2013, Vol. 19 Issue 6, p766, 10 p.
Publication Year :
2013

Abstract

Glucagon activates hepatic protein kinase A (PKA) to increase glucose production (1), (2), but the glucostimulatory effect is transient even in the presence of continuous intravenous glucagon infusion (3-5). Continuous [...]

Details

Language :
English
ISSN :
10788956
Volume :
19
Issue :
6
Database :
Gale General OneFile
Journal :
Nature Medicine
Publication Type :
Academic Journal
Accession number :
edsgcl.334606589
Full Text :
https://doi.org/10.1038/nm.3115