Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6

Authors :: Feo, Maria Luisa
Gross, Michael S.
McGarrigle, Barbara P.
Eljarrat, Ethel
Barcelo, Damia
Aga, Diana S.
Olson, James R.
Source :: Environmental Health Perspectives. April 2013, Vol. 121 Issue 4, p440, 14 p.
Publication Year :: 2013
Abstract: BACKGROUND: Previous studies have indicated that cytochrome P450s (CYPs) are involved in the metabolism of polybrominated diphenyl ether (PBDE) flame retardants in humans, resulting in the formation of hydroxylated PBDEs [...]

Subjects :: Research
Health aspects
Cytochrome P-450 -- Physiological aspects -- Health aspects
Flame retardants -- Health aspects
Metabolism -- Research
Fireproofing agents -- Health aspects

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