APOBEC3B is an enzymatic source of mutation in breast cancer

Authors :: Burns, Michael B.
Lackey, Lela
Carpenter, Michael A.
Rathore, Anurag
Land, Allison M.
Leonard, Brandon
Refsland, Eric W.
Kotandeniya, Delshanee
Tretyakova, Natalia
Nikas, Jason B.
Yee, Douglas
Temiz, Nuri A.
Donohue, Duncan E.
McDougle, Rebecca M.
Brown, William L.
Law, Emily K.
Harris, Reuben S.
Source :: Nature. February 21, 2013, Vol. 494 Issue 7437, p366, 6 p.
Publication Year :: 2013
Abstract: Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions (1-9). Most of these [...]

Subjects :: Gene mutations -- Observations
Tumors -- Genetic aspects
Hydrolases -- Properties
Enzymes -- Properties
Neoplastic processes -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation

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