Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations

Authors :: Subauste, Angela R.
Das, Arun K.
Li, Xiangquan
Elliot, Brandon
Evans, Charles
Azzouny, Mahmoud El
Treutelaar, Mary
Oral, Elif
Leff, Todd
Burant, Charles F.
Source :: Diabetes. November 1, 2012, Vol. 61 Issue 11, p2922, 10 p.
Publication Year :: 2012
Abstract: Congenital generalized lipodystrophy (CGL), secondary to AGPAT2 mutation is characterized by the absence of adipocytes and development of severe insulin resistance. In the current study, we investigated the adipogenic defect [...]

Subjects :: Adipose tissues -- Research -- Analysis
Lipodystrophy -- Genetic aspects -- Development and progression -- Physiological aspects -- Research
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