A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Authors :: Kruidenier, Laurens
Chung, Chun-wa
Cheng, Zhongjun
Liddle, John
Che, KaHing
Joberty, Gerard
Bantscheff, Marcus
Bountra, Chas
Bridges, Angela
Diallo, Hawa
Eberhard, Dirk
Hutchinson, Sue
Jones, Emma
Katso, Roy
Leveridge, Melanie
Mander, Palwinder K.
Mo sley, Julie
Ramirez-Molina, Cesar
Rowland, Paul
Schofield, Christopher J.
Sheppard, Robert J.
Smith, Julia E.
Swales, Catherine
Tanner, Robert
Thomas, Pamela
Tumber, Anthony
Drewes, Gerard
Oppermann, Udo
Patel, Dinshaw J.
Lee, Kevin
Wilson, David M.
Source :: Nature. August 16, 2012, Vol. 488 Issue 7411, p404, 5 p.
Publication Year :: 2012
Abstract: The jumonji (JMJ) family of histone demethylases are [Fe.sup.2+] and a-ketoglutarate-dependent oxygenases that are essential components of regulatory transcriptional chromatin complexes (1-4). These enzymes demethylate lysine residues in histones in [...]

Subjects :: Physiological aspects
Research
Macrophages -- Physiological aspects -- Research
Transcription (Genetics) -- Research
Enzymes -- Genetic aspects -- Physiological aspects -- Research
Genetic transcription -- Research

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