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AICAR prevents heat-induced sudden death in ryr1 mutant mice independent of AMPK activation
- Source :
- Nature Medicine. February 1, 2012, Vol. 18 Issue 2, p244, 9 p.
- Publication Year :
- 2012
-
Abstract
- Mice with a knock-in mutation (Y524S) in the type I ryanodine receptor (Ryr1), a mutation analogous to the Y522S mutation that is associated with malignant hyperthermia in humans, die when [...]
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 18
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.280558730
- Full Text :
- https://doi.org/10.1038/nm.2598