Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

Authors :: Keryer, Guy
Pineda, Jose R.
Liot, Geraldine
Kim, Jinho
Dietrich, Paula
Benstaali, Caroline
Smith, Karen
Cordelieres, Fabrice P.
Spassky, Nathalie
Ferrante, Robert J.
Dragatsis, Ioannis
Saudou, Frederic
Source :: Journal of Clinical Investigation. November 1, 2011, Vol. 121 Issue 11, p4372, 11 p.
Publication Year :: 2011
Abstract: Huntington disease (HD) is a devastating autosomal-dominant neurodegenerative disorder. It is caused by expansion of a CAG repeat in the first exon of the huntingtin (HTT) gene that encodes a [...]

Subjects :: Cilia and ciliary motion -- Growth -- Genetic aspects
Huntington's chorea -- Diagnosis -- Care and treatment
Genetic regulation -- Research
Company growth
Health care industry

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