Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

Authors :: Ebi, Hiromichi
Corcoran, Ryan B.
Singh, Anurag
Chen, Zhao
Song, Youngchul
Lifshits, Eugene
Ryan, David P.
Meyerhardt, Jeffrey A.
Benes, Cyril
Settleman, Jeffrey
Wong, Kwok-Kin
Cantley, Lewis C.
Engelman, Jeffrey A.
Source :: Journal of Clinical Investigation. November 1, 2011, Vol. 121 Issue 11, p4311, 11 p.
Publication Year :: 2011
Abstract: Therapies inhibiting receptor tyrosine kinases (RTKs) are effective against some human cancers when they lead to simultaneous downregulation of PI3K/AKT and MEK/ERK signaling. However, mutant KRAS has the capacity to [...]

Subjects :: Tyrosine -- Properties
Gene mutations -- Identification and classification
Colorectal cancer -- Diagnosis -- Care and treatment
Cellular signal transduction -- Genetic aspects
Genetic regulation -- Research
Health care industry

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