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The consequence of immune suppressive cells in the use of therapeutic cancer vaccines and their importance in immune monitoring

The consequence of immune suppressive cells in the use of therapeutic cancer vaccines and their importance in immune monitoring

Authors :
Vergati, Matteo
Schlom, Jeffrey
Tsang, Kwong Y.
Source :
Journal of Biomedicine and Biotechnology. Annual 2011
Publication Year :
2011

Abstract

1. Introduction In April 2010, the U.S. Food and Drug Administration (FDA) approved sipuleucel-T (Provenge, Dendreon Corp., Seattle, WA) for the treatment of asymptomatic or minimally symptomatic metastatic castration-resistant prostate [...]<br />Evaluating the number, phenotypic characteristics, and function of immunosuppressive cells in the tumor microenvironment and peripheral blood could elucidate the antitumor immune response and provide information to evaluate the efficacy of cancer vaccines. Further studies are needed to evaluate the correlation between changes in immunosuppressive cells and clinical outcomes of patients in cancer vaccine clinical trials. This paper focuses on the role of T-regulatory cells, myeloid-derived suppressor cells, and tumor-associated macrophages in cancer and cancer immunotherapy and their role in immune monitoring.

Details

Language :
English
ISSN :
11107243
Database :
Gale General OneFile
Journal :
Journal of Biomedicine and Biotechnology
Publication Type :
Academic Journal
Accession number :
edsgcl.266629930
Full Text :
https://doi.org/10.1155/2011/182413