Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

Authors :: Cao, Kan
Blair, Cecilia D.
Faddah, Dina A.
Kieckhaefer, Julia E.
Olive, Michelle
Erdos, Michael R.
Nabel, Elizabeth G.
Collins, Francis S.
Source :: Journal of Clinical Investigation. July 1, 2011, Vol. 121 Issue 7, p2833, 12 p.
Publication Year :: 2011
Abstract: Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disease, is caused by a point mutation in the lamin A gene (LMNA). This mutation constitutively activates a cryptic splice donor site, [...]

Subjects :: Gene mutations -- Health aspects -- Research
Progeria -- Risk factors -- Genetic aspects -- Research
Fibroblasts -- Physiological aspects -- Genetic aspects -- Research
Telomeres -- Physiological aspects -- Research
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