TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

Authors :: Welford, Abigail F.
Biziato, Daniela
Coffelt, Seth B.
Nucera, Silvia
Fisher, Matthew
Pucci, Ferdinando
Di Serio, Clelia
Naldini, Luigi
De Palma, Michele
Tozer, Gillian M.
Lewis, Claire E.
Source :: Journal of Clinical Investigation. May, 2011, Vol. 121 Issue 5, p1969, 5 p.
Publication Year :: 2011
Abstract: Vascular-disrupting agents (VDAs) such as combretastatin A4 phosphate (CA4P) selectively disrupt blood vessels in tumors and induce tumor necrosis. However, tumors rapidly repopulate after treatment with such compounds. Here, we [...]

Subjects :: Tumors -- Research -- Drug therapy
Angiogenesis inhibitors -- Health aspects -- Research
Macrophages -- Physiological aspects -- Research -- Health aspects
Health care industry

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