Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

Authors :: Holland, William L.
Bikman, Benjamin T.
Wang, Li-Ping
Yuguang, Guan
Sargent, Katherine M.
Bulchand, Sarada
Knotts, Trina A.
Shui, Guanghou
Clegg, Deborah J.
Wenk, Markus R.
Pagliassotti, Michael J.
Scherer, Philipp E.
Summers, Scott A.
Source :: Journal of Clinical Investigation. May 1, 2011, Vol. 121 Issue 5, p1858, 13 p.
Publication Year :: 2011
Abstract: Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One mechanism accounting for the increased inflammation associated with obesity [...]

Subjects :: Lipids -- Physiological aspects -- Research
Ceramides -- Physiological aspects -- Research
Insulin resistance -- Risk factors -- Research
Toll-like receptors -- Physiological aspects -- Research
Health care industry

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