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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
- Source :
- Nature. April 14, 2011, Vol. 472 Issue 7342, p226, 5 p.
- Publication Year :
- 2011
-
Abstract
- Genetic studies indicate that protein homeostasis is a major contributor to metazoan longevity (1). Collapse of protein homeostasis results in protein misfolding cascades and the accumulation of insoluble protein fibrils [...]
- Subjects :
- Caenorhabditis elegans -- Genetic aspects -- Research -- Physiological aspects
Aging -- Physiological aspects -- Genetic aspects -- Research
Homeostasis -- Physiological aspects -- Genetic aspects -- Research
Amyloid beta-protein -- Physiological aspects -- Genetic aspects -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation
Subjects
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 472
- Issue :
- 7342
- Database :
- Gale General OneFile
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.254484710
- Full Text :
- https://doi.org/10.1038/nature09873