Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery

Introduction C-reactive protein (CRP) is a reactant involved in the acute-phase response and rapidly increases in the presence of infection or inflammation (Kushner and Rzewnicki, 1999). CRP production is stimulated [...]
Background/objectives: C-reactive protein (CRP) is the most extensively studied inflammatory risk marker, and elevated serum CRP concentrations in pregnant women are known to be associated with subsequent development of preeclampsia and preterm delivery. Researchers have suggested that folate intake may help to control the inflammation process. We examined whether folate nutrition modifies the relationship between serum CRP concentration and gestational age at delivery. Subjects/methods: Serum CRP concentrations were analyzed in 815 pregnant women between 12 and 28 weeks of gestation. Dietary intakes were assessed using a 24-h dietary recall. The serum folate and high-sensitivity CRP concentrations were analyzed by radioassay and latex agglutination tests, respectively. Results: Serum CRP concentration was negatively correlated (P< 0.001) with gestational age at delivery. Serum folate concentration was negatively correlated (P Conclusions: We found that adequate maternal folate intake during pregnancy may have a beneficial role against shorter gestational age at delivery, which is associated with higher serum CRP concentrations in pregnant women. European Journal of Clinical Nutrition (2011) 65, 350-356; doi: 10.1038/ejcn.2010.267; published online 22 December 2010 Keywords: folate; high-sensitivity CRP; gestational age at delivery; pregnant women