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Amyloid fibril polymorphism is under kinetic control
- Source :
- Journal of the American Chemical Society. Oct 27, 2010, Vol. 132 Issue 42, 14960-14970
- Publication Year :
- 2010
-
Abstract
- The nucleation of distinct fibril morphologies is examined by using computer simulations of a simplified model of an amyloid polypeptide. The free-energy profiles of the aggregation process has shown that the nucleation barrier has determined the population fractions of different fibril morphologies, that is, amyloid polymorphism is under kinetic control.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 132
- Issue :
- 42
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.242062490