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PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
- Source :
- Journal of Clinical Investigation. July, 2010, Vol. 120 Issue 7, p2508, 8 p.
- Publication Year :
- 2010
-
Abstract
- The inhibitory receptor programmed death 1 (PD-1) is upregulated on antigen-specific [CD8.sup.+] T cells during persistent viral infections. Interaction with PD-1 ligand 1 (PD-L1) contributes to functional exhaustion of responding T cells and may limit immunopathology during infection. PD-L1 is expressed on both hematopoietic and nonhematopoietic cells in tissues. However, the exact roles of PD-L1 on hematopoietic versus nonhematopoietic cells in modulating immune responses are unclear. Here we used bone marrow chimeric mice to examine the effects of PD-L1 deficiency in hematopoietic or nonhematopoietic cells during lymphocytic choriomeningitis virus clone 13 (LCMV CL-13) infection. We found that PD-L1 expression on hematopoietic cells inhibited [CD8.sup.+] T cell numbers and function after LCMV CL-13 infection. In contrast, PD-L1 expression on nonhematopoietic cells limited viral clearance and immunopathology in infected tissues. Together, these data demonstrate that there are distinct roles for PD-L1 on hematopoietic and nonhematopoietic cells in regulating [CD8.sup.+] T cell responses and viral clearance during chronic viral infection.<br />Introduction We recently identified a major inhibitory pathway consisting of the inhibitory receptor programmed death 1 (PD-1) and its ligand PD-1 ligand 1 (PD-L1) involved in T cell exhaustion during [...]
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 120
- Issue :
- 7
- Database :
- Gale General OneFile
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.241874176
- Full Text :
- https://doi.org/10.1172/JCI40040