Risk of intraoperative hypotension with loop diuretics: A randomized controlled trial

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2010.07.019 Byline: Nadia A. Khan (a), Norman R. Campbell (b), Shaun D. Frost (c), Ken Gilbert (d), Frank A. Michota (e), Ali Usmani (e), Doug Seal (f), William A. Ghali (b)(g) Keywords: Furosemide; Intraoperative hypotension; Perioperative; Surgery Abstract: There is growing concern regarding the safety of blood pressure-lowering medications administered during the perioperative period. Whether loop diuretics also induce intraoperative hypotension is uncertain. Our objective was to compare the effects of continuing or withholding furosemide on the day of noncardiac elective surgery on intraoperative hypotension among chronic users of furosemide. Author Affiliation: (a) Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (b) Department of Medicine and Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (f) Department of Anesthesia, University of Calgary, Calgary, Alberta, Canada (g) Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada (c) Department of Medicine, University of Minnesota, and Cogent Healthcare, Minneapolis (d) Department of Medicine, University of Western Ontario, London, Ontario, Canada (e) Department of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, Ohio Article Note: (footnote) Funding: Supported by the Center for Advancement of Health, University of Calgary, and the Cleveland Clinic Foundation. Drs. Khan and Ghali received support from Alberta Heritage Foundation of Medical Research, Canadian Institutes of Health Research. Dr. Ghali received support from the Canadian Research Chairs program., Conflict of Interest: There are no conflicts of interest with this work for any of the authors., Authorship: All authors had access to the data, made significant contributions to writing the manuscript, and met authorship criteria.