The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy)

Authors :: Van, Linh M.
Heydari, Amir
Yang, Jiansong
Hargreaves, Judith
Rowland-Yeo, Karen
Lennard, Martin S.
Tucker, Geoffrey T.
Rostami-Hodjegan, Amin
Source :: Journal of Psychopharmacology. November 1, 2006, Vol. 20 Issue 6, p834, 8 p.
Publication Year :: 2006
Abstract: Abstract MDMA (3-4-methylenedioxymethamphetamine, commonly known as Ecstasy) is a potent mechanism-based inhibitor (MBI) of cytochrome P450 2D6 (CYP2D6), causing quasi-irreversible inhibition of the enzyme in vitro. An evaluation of the [...]

Subjects :: Ecstasy (Drug) -- Dosage and administration -- Surveys -- Analysis -- Genetic aspects -- Research
Cytochrome P-450 -- Surveys -- Analysis -- Physiological aspects -- Genetic aspects -- Research
Pharmacogenetics -- Research
Pharmaceuticals and cosmetics industries
Psychology and mental health
Physiological aspects
Genetic aspects
Research
Dosage and administration

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