Pd-catalyzed intermolecular ortho-C-H amidation of anilides by N-nosyloxycarbamate

A palladium-catalyzed ortho-C-H amidation of anilides by N-nosyloxycarbamates which could be carried out under relatively mild conditions was developed for the synthesis of 2-aminoanilines. The amidation reaction is found to be probably initiated by rate-limiting C-H cyclopalladation to form an arylpalladium complex, followed by nitrene functionalization.