Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality

Authors :: Domchek, Susan M.
Friebel, Tara M.
Singer, Christian F.
Evans, D. Gareth
Lynch, Henry T.
Isaacs, Claudine
Garber, Judy E.
Neuhausen, Susan L.
Matloff, Ellen
Eeles, Rosalind
Pichert, Gabriella
Van tEveer, Laura
Tung, Nadine
Weitzel, Jeffrey N.
Couch, Fergus J.
Rubinstein, Wendy S.
Ganz, Patricia A.
Daly, Mary B.
Olopade, Olufunmilayo I.
Tomlinson, Gail
Schildkraut, Joellen
Blum, Joanne L.
Rebbeck, Timothy R.
Source :: JAMA, The Journal of the American Medical Association. Sept 1, 2010, Vol. 304 Issue 9, p967, 9 p.
Publication Year :: 2010
Abstract: A study was conducted to estimate the risk and mortality reduction by BRCA1 or BRCA2 mutations and prior cancer status. Results indicated that among women with BRCA1 or BRCA2, risk-reducing mastectomy was associated with a lower risk of breast cancer and cancer-related mortality.

Subjects :: Breast cancer -- Diagnosis
Breast cancer -- Care and treatment
Breast cancer -- Risk factors
Breast cancer -- Genetic aspects
Mastectomy -- Health aspects
BRCA mutations -- Research

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