A covalent succinylcysteine-like intermediate in the enzyme-catalyzed transformation of maleate to fumarate by maleate isomerase

Authors :: Fisch, Florian
Fleites, Carlos Martinez
Delenne, Marie
Hauer, Bernhard
Baudendistel, Nina
Turkenburg, Johan P.
Hart, Sam
Bruce, Neil C.
Grogan, Gideon
Source :: Journal of the American Chemical Society. August 25, 2010, Vol. 132 Issue 33, 11455-11457
Publication Year :: 2010
Abstract: Several mutation studies are conducted to analyze the significance of maleate isomerase (MI) in the catalysis of the cis-trans isomerization of the double bond present in the maleate. The formation of the covalent succinylcysteine-like intermediate during the isomerization process is also discussed.

Subjects :: Catalysis -- Analysis
Cysteine -- Chemical properties
Gene mutations -- Analysis
Isomerization -- Analysis
Nocardia -- Genetic aspects
Chemistry

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