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A mathematical modeling approach to characterize hormesis, caloric restriction and toxicity in mortality data from toxicity studies

Authors :
Neafsey, Patricia J.
Source :
American Journal of Pharmacology and Toxicology. Jan, 2008, Vol. 3 Issue 1, p80, 13 p.
Publication Year :
2008

Abstract

The mortality of a population reflects the combined effects of natural aging with environmental insults (e.g. toxicant exposure, caloric restriction, over feeding, infections, etc.). No single endpoint, such as carcinogenesis, completely describes toxicant-induced effects in laboratory animals. Mathematical models of mortality and time-dependent exposure to toxicants can yield indices of net injury from all causes. With careful manipulation of diet in control groups, the separate and combined effects of hormesis, caloric restriction and toxicity on mortality can be delineated. In particular, age-specific mortality rate analyses can characterize a) the temporal pattern of net injury from acute, short term and chronic environmental exposure, b) late-life effects, c) effects of fractional exposures and d) relative biological effectiveness. Changes in the design of toxicity studies and analyses of mortality data are suggested. Key words: Hormesis, caloric restriction, mortality, chronic toxicity<br />INTRODUCTION Hormesis and caloric restriction have been considered as related phenomena in laboratory rodents (see Human and Experimental Toxicology vol. 19 no 6, 2000). [1] Laboratory rodents are typically inbred [...]

Details

Language :
English
ISSN :
15574962
Volume :
3
Issue :
1
Database :
Gale General OneFile
Journal :
American Journal of Pharmacology and Toxicology
Publication Type :
Academic Journal
Accession number :
edsgcl.237348308