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Interaction and localization of the retinitis pigmentosa protein RP2 and NSF in retinal photoreceptor cells
- Source :
- Biochemistry. Sept 7, 2010, Vol. 49 Issue 35, 7439-7447
- Publication Year :
- 2010
-
Abstract
- Biochemical studies are conducted to identify proteins in retinal cell extracts that interact with RP2 in order to define the role of RP2 in the retina and X-linked retinitis pigmentosa (XLRP). The studies have shown that RP2, in addition to serving as a regulator of ADP ribosylation factor-like 3 (Arl3), has interacted with N-ethylmaleimide sensitive factor (NSF) and the complex has played a vital role in membrane protein trafficking in photoreceptors and other cells of the retina.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 49
- Issue :
- 35
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.237258712