Estradiol binding prevents ApoB-100 misfolding in electronegative LDL(-)

Electronegative LDL(-) is spontaneously produced in vitro by plasma incubation through phospholipid hydrolysis catalyzed by the activity of endogeneous phospholipases and hence apoprotein misfolding is proposed as a possible antherogenic modification. The studies have shown that electronegative charge and misfolding are independent and distinct features of LDL(-) and apoprotein and misfolding rather than the increase in the negative charge has emerged both as a valid biomarker and as an appealing pharmacological and nutritional target.