Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection

Authors :: Zhernakova, Alexandra
Elbers, Clara C.
Ferwerda, Bart
Romanos, Jihane
Trynka, Gosia
Dubois, Patrick C.
de Kovel, Carolien G.F.
Franke, Lude
Oosting, Marije
Barisani, Donatella
Bardella, Maria Teresa
Joosten, Leo A.B.
Saavalainen, Paivi
van Heel, David A.
Catassi, Carlo
Netea, Mihai G.
Wijmenga, Cisca
Source :: American Journal of Human Genetics. June 11, 2010, Vol. 86 Issue 6, p970, 8 p.
Publication Year :: 2010
Abstract: The integrated haplotype score method is employed for a complete evolutionary, as well as functional analysis of the risk loci of the celiac disease. The analyses prove that SH2B3 plays an extremely significant factor for protecting people against bacterial infection.

Subjects :: Bacterial infections -- Prevention
Celiac disease -- Genetic aspects
Celiac disease -- Research
Haplotypes -- Research
Lipopolysaccharides -- Health aspects
Biological sciences

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