Rationale and design of a randomized clinical trial to assess the safety and efficacy of frequent optimization of cardiac resynchronization therapy: The Frequent Optimization Study Using the QuickOpt Method (FREEDOM) trial

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2010.02.034 Byline: William T. Abraham (a), Daniel Gras (b), Cheuk Man Yu (c), Lisa Guzzo (d), Manish S. Gupta (e) Abstract: The aim of the study was to describe the rationale, design, and end points of a randomized, double-blind, controlled trial evaluating frequent systematic optimization of atrioventricular (AV) and interventricular (VV) delays in patients receiving cardiac resynchronization therapy (CRT). Author Affiliation: (a) The Ohio State University, Columbus, OH (b) Nouvelles Cliniques Nantaises, Nantes, France (c) Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, P.R. China (d) St Jude Medical, Brussels, Belgium (e) St Jude Medical, Sylmar, CA Article History: Received 19 April 2009; Accepted 24 February 2010 Article Note: (footnote) RCT Reg #NCT00418314.