Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle

Authors :: Cosconati, Sandro
Marinelli, Luciana
Trotta, Roberta
Virno, Ada
De Tito, Stefano
Romagnoli, Romeo
Pagano, Bruno
Limongelli, Vittorio
Giancola, Concetta
Baraldi, Pier Giovanni
Mayo, Luciano
Novellino, Ettore
Randazzo, Antonio
Source :: Journal of the American Chemical Society. May 12, 2010, Vol. 132 Issue 18, 6425-6433
Publication Year :: 2010
Abstract: Several studies are conducted to determine the structural and conformational requisites that are required for the DNA quadruplex groove binding. Distamycin A is shown to be the only compound exhibiting a pure groove binding.

Subjects :: Antimitotic agents -- Chemical properties
Antineoplastic agents -- Chemical properties
DNA -- Structure
DNA -- Chemical properties
DNA-ligand interactions -- Analysis
Electrostatic interactions -- Analysis
Chemistry

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