Effect of lipid type on the binding of lipid vesicles to islet amyloid polypeptide amyloid fibrils

Authors :: Sasahara, Kenji
Hall, Damien
Hamada, Daizo
Source :: Biochemistry. April 13, 2010, Vol. 49 Issue 14, 3040-3048
Publication Year :: 2010
Abstract: Turbidity measurements were conducted to provide a detailed description of the binding reaction between islet amyloid polypeptide (IAPP) fibrils and lipid vesicles prepared from phosphatidylcholine. The obtained data and simulation predictions provide insight into the potential roles of IAPP amyloid fibrils in membrane binding.

Subjects :: Glycoproteins -- Structure
Glycoproteins -- Chemical properties
Pancreatic beta cells -- Physiological aspects
Pancreatic beta cells -- Genetic aspects
Lecithin -- Chemical properties
Protein binding -- Analysis
Biological sciences
Chemistry

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