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Allelic skewing of DNA methylation is widespread across the genome

Authors :
Schalkwyk, Leonard C.
Meaburn, Emma L.
Smith, Rebecca
Dempster, Emma L.
Jeffries, Aaron R.
Davies, Matthew N.
Plomin, Robert
Mill, Jonathan
Source :
American Journal of Human Genetics. Feb 12, 2010, Vol. 86 Issue 2, p196, 17 p.
Publication Year :
2010

Abstract

A genome-wide survey investigates the level of allelic skewing of DNA methylation in order to identify previously unknown differentially methylated regions (DMRs) mainly associated with DNA sequence variation acting in cis or genomic imprinting. A quantitative assessment of allele-specific DNA methylation (ASM) using SNP microarrays reveals that allelic skewing of DNA methylation is widespread across the genome, with likely heterogeneity between individuals and across tissues.

Subjects

Subjects :
Methylation -- Research
Nucleotide sequence -- Research
Allelomorphism -- Research
Biological sciences

Details

Language :
English
ISSN :
00029297
Volume :
86
Issue :
2
Database :
Gale General OneFile
Journal :
American Journal of Human Genetics
Publication Type :
Academic Journal
Accession number :
edsgcl.223631704

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