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CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus
- Source :
- Science. March 19, 2010, Vol. 327 Issue 5972, p1518, 5 p.
- Publication Year :
- 2010
-
Abstract
- CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1-and A2-mediated steady-state currents, but did not affect kainate-or N-methyl-D-aspartate (NMDA) receptor--mediated currents. Mouse hippocampal CA1 pyramidal neurons expressed CKAMP44 at low abundance, and overexpression of CKAMP44 led to stronger and faster AMPA receptor desensitization, slower recovery from desensitization, and a reduction in the paired-pulse ratio of AMPA currents. By contrast, dentate gyrus granule cells exhibited strong CKAMP44 expression, and CKAMP44 knockout increased the paired-pulse ratio of AMPA currents in lateral and medial perforant path--granule ceil synapses. CKAMP44 thus modulates short-term plasticity at specific excitatory synapses. 10.1126/science.1184178
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 327
- Issue :
- 5972
- Database :
- Gale General OneFile
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.222558246
- Full Text :
- https://doi.org/10.1126/science.1184178