An efficient catalyst system for Pd-catalyzed amination of [2.2] paracyclophanyl bromides

The development of a practical Buchwald-Hartwig amination of [2.2]paracyclophanyl bromides with benzhydrylideneamine is described. The method has provided a facile route to a variety of imino and amino [2.2]paracyclophanes that are otherwise not readily synthesized.