Mutations of the SYCP3 gene in women with recurrent pregnancy loss

The studies related to the mutations in SYCP3, a gene encoding an essential component of the synaptonemal complex that is central to the interaction of homologous chromosomes, and its association with recurrent pregnancy loss in humans is reported. The results revealed that generation of an aberrant synaptonemal complex in a dominant-negative manner, during mutations might contribute to abnormal chromosomal behavior that might lead to recurrent miscarriage.