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Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
- Source :
- Nature Medicine. March 1, 2010, Vol. 16 Issue 3, p319, 6 p.
- Publication Year :
- 2010
-
Abstract
- The worldwide diversity of HIV-1 presents an unprecedented challenge for vaccine development (1,2). Antigens derived from natural HIV-1 sequences have elicited only a limited breadth of cellular immune responses in nonhuman primate studies and clinical trials to date. Polyvalent 'mosaic' antigens, in contrast, are designed to optimize cellular immunologic coverage of global HIV-1 sequence diversity (3). Here we show that mosaic HIV-1 Gag, Pol and Env antigens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors markedly augmented both the breadth and depth without compromising the magnitude of antigen-specific T lymphocyte responses as compared with consensus or natural sequence HIV-1 antigens in rhesus monkeys. Polyvalent mosaic antigens therefore represent a promising strategy to expand cellular immunologic vaccine coverage for genetically diverse pathogens such as HIV-1.<br />The development of vaccine strategies that expand cellular immune breadth will be crucial for achieving immunologic coverage of the enormous global genetic diversity of HIV-1 (1,2). Moreover, the breadth of [...]
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 16
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.221203985
- Full Text :
- https://doi.org/10.1038/nm.2089