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Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPAR[gamma]

Authors :
Evans, Nicholas P.
Misyak, Sarah A.
Schmelz, Eva M.
Guri, Amir J.
Hontecillas, Raquel
Bassaganya-Riera, Josep
Source :
The Journal of Nutrition. March, 2010, Vol. 140 Issue 3, p515, 7 p.
Publication Year :
2010

Abstract

Conjugated linoleic acid (CLA) exerts a protective effect on experimental inflammatory bowel disease and shows promise as a chemopreventive agent against colorectal cancer (CRC) in mice, although the mechanisms by which it exerts its beneficial effects against malignancies in the gut are not completely understood. Mice lacking PPAR[gamma], in immune and epithelial cells and PPAR[gamma]/-expressing littermates were fed either control or CLA-supplemented (1 g CLA/100 g) diets to determine the role of PPAR[gamma], in inflammation-induced CRC. To induce tumor formation and colitis, mice were treated with azoxymethane and then challenged with 2% dextran sodium sulfate, respectively. Dietary CLA ameliorated disease activity, decreased colitis, and prevented adenocarcinoma formation in the PPAR[gamma],-expressing floxed mice but not in the tissue-specific PPAR[gamma]-null mice. Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPAR[gamma]expressing, but not in the tissue-specific, PPAR-),-null mice. Colonic tumor necrosis factor-[alpha] mRNA expression was significantly suppressed in CLA-fed, PPAR[gamma]-expressing mice. This study suggests CLA ameliorates colitis and prevents tumor formation in part through a PPAR[gamma]-dependent mechanism. doi: 10.3945/jn.109.115642.

Details

Language :
English
ISSN :
00223166
Volume :
140
Issue :
3
Database :
Gale General OneFile
Journal :
The Journal of Nutrition
Publication Type :
Academic Journal
Accession number :
edsgcl.221203549