A method for the synthesis of substituted quinolines via electrophilic cyclization of 1-azido-2-(2-propynyl)benzene

A new and efficient method was developed for the synthesis of substituted quinolines via intramolecular electrophilic cyclization of 1-azido-2-(2-propynyl)benzene. The cyclization reaction was performed in the of electrophilic reagents ([I.sub.2], [Br.sub.2], ICl, NBS, NIS, and HNT[f.sub.2]) in [CH.sub.3]N[O.sub.2] at room temperature or in the presence of catalytic amounts of Au[Cl.sub.3]/AgNT[f.sub.2] in THF at 100 degree [Celsius] to afford the corresponding quinolines.