Solid-phase microextraction for the detection of codeine, morphine and 6-monoacetylmorphine in human hair by gas chromatography-mass spectrometry

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.forsciint.2009.12.046 Byline: M. Moller (a)(b), K. Aleksa (a), P. Walasek (a), T. Karaskov (a), G. Koren (a)(b) Keywords: Solid-phase microextraction; Hair analysis; Opiates; Gas chromatography-mass spectrometry Abstract: Opiate hair analysis continues to prove difficult due to the scarcity of hair sample and low drug concentrations. For this reason, we developed a sensitive method utilizing headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) for the detection of three principle opiates; codeine, morphine, and 6-acetylmorphine. Author Affiliation: (a) Motherisk Program, Division of Clinical Pharmacology & Toxicology, Hospital for Sick Children, , Toronto, Ontario Canada, M5G1X8 (b) Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada Article History: Received 9 June 2009; Accepted 21 July 2009