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Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
- Source :
- American Journal of Human Genetics. Jan 8, 2010, Vol. 86 Issue 1, p88, 5 p.
- Publication Year :
- 2010
-
Abstract
- A study identifies genetic predictors of lymphocyte levels, which are hypothesized to be associated with immune-related diseases, and tests several variants of CD4+ T cells, CD8+ T cells, CD56+ natural killer (NK) cells and the derived CD4:CD8 ratio associated with five lymphocyte subsets. It identifies two major independent quantitative trait loci (QTL) for CD4:CD8 lymphocyte ratio, wherein CD4 and CD8 are associated with risk of type-1 diabetes and HIV-1 immune control, respectively.
- Subjects :
- HIV infection -- Genetic aspects
HIV infection -- Risk factors
Immunologic diseases -- Genetic aspects
Lymphocytes -- Health aspects
Major histocompatibility complex -- Research
Quantitative trait loci -- Research
Type 1 diabetes -- Genetic aspects
Type 1 diabetes -- Risk factors
Biological sciences
Subjects
Details
- Language :
- English
- ISSN :
- 00029297
- Volume :
- 86
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- American Journal of Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.219037707