Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control

Authors :: Ferreira, Manuel A.R.
Mangino, Massimo
Brumme, Chanson J.
Zhen Zhen Zhao
Medland, Sarah E.
Nyholt, Dale R.
Wright, Margaret J.
Gordon, Scott
Campbell, Megan
Henders, Anjali
Evans, David M.
Lanchbury, Jerry S.
Pereyra, Florencia
McEvoy, Brian P.
Walker, Bruce D.
Haas, David W.
Soranzo, Nicole
Spector, Tim D.
de Bakker, Paul I.W.
Frazer, Ian H.
Montgomery, Grant W.
Martin, Nicholas G.
Source :: American Journal of Human Genetics. Jan 8, 2010, Vol. 86 Issue 1, p88, 5 p.
Publication Year :: 2010
Abstract: A study identifies genetic predictors of lymphocyte levels, which are hypothesized to be associated with immune-related diseases, and tests several variants of CD4+ T cells, CD8+ T cells, CD56+ natural killer (NK) cells and the derived CD4:CD8 ratio associated with five lymphocyte subsets. It identifies two major independent quantitative trait loci (QTL) for CD4:CD8 lymphocyte ratio, wherein CD4 and CD8 are associated with risk of type-1 diabetes and HIV-1 immune control, respectively.

Subjects :: HIV infection -- Genetic aspects
HIV infection -- Risk factors
Immunologic diseases -- Genetic aspects
Lymphocytes -- Health aspects
Major histocompatibility complex -- Research
Quantitative trait loci -- Research
Type 1 diabetes -- Genetic aspects
Type 1 diabetes -- Risk factors
Biological sciences

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