Large, rare chromosomal deletions associated with severe early-onset obesity

Obesity is a highly heritable and genetically heterogeneous disorder (1). Here we investigated the contribution of copy number variation to obesity in 300 Caucasian patients with severe early-onset obesity, 143 of whom also had developmental delay. Large (>500 kilobases), rare (
Although the rise in obesity prevalence is driven by environmental factors, there is considerable evidence that weight is highly heritable (1,7). Genome-wide association studies (GWAS) have identified common single nucleotide [...]