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Kinetic stability of the flavin semiquinone in photolyase and cryptochrome-DASH

Authors :
Damiani, Michael J.
Yalloway, Gary N.
Lu, Jessica
McLeod, Neahlanna R.
O'Neill, Melanie A.
Source :
Biochemistry. Dec 8, 2009, Vol. 48 Issue 48, 11399-11411
Publication Year :
2009

Abstract

A study was conducted to understand the kinetic mechanism related to the role of structurally homologous flavoproteins photolyases and cryptochromes (CRY) towards UV-damaged DNA repair by photoinduced electron transfer from their FAD cofactor. The results obtained offer insight into the kinetic tuning of the rates of electron transfer which would play a function-defining role in photolyases and cryptochromes.

Subjects

Subjects :
Cytochromes -- Chemical properties
Cytochromes -- Structure
DNA repair -- Analysis
Electron transport -- Analysis
Bioflavonoids -- Chemical properties
Bioflavonoids -- Structure
Flavones -- Chemical properties
Flavones -- Structure
Flavonoids -- Chemical properties
Flavonoids -- Structure
Photolysis -- Analysis
Biological sciences
Chemistry

Details

Language :
English
ISSN :
00062960
Volume :
48
Issue :
48
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.214764023

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